Skip to main content

Scientists analysed the proteome of T helper 17 cells

T helper 17 (T-h17) cells have essential functions in autoimmune diseases and inflammation belonging to a group of T cells. To maintain self-tolerance and prevent autoimmune responses, Regulatory T cells (iTregs) are used to function suppressively.


Proteins are one of the important biomolecules forming the functional and structural entity of a living cell. To determine the set of proteins expressed by a cell, tissue, or organism at a certain time mass spectrometry-based quantitative proteomics can be used.
The immune system protects the body against harmful pathogens and tumors providing self-tolerance. T-helper cells play critical roles in controlling immune reactions as they are the major components of the adaptive system.

The label-free quantitative proteomics which is an advanced technology is utilized to identify the proteomes of Th17 and iTreg cells. This technology has generated a resource that is used to identify over 4000 proteins expressed in Th17 and iTreg cells.


The analysis of both proteome and gene expression data was combined to discover the changes in protein expression that was not associated with changes at the transcriptional level. The identified proteins are targeted potentially in immunotherapy for disease conditions like cancer and autoimmunity.

Comments

Popular posts from this blog

Photosynthetic protein structure that harvests and traps infrared light

Scientist finds the solution for the structure of a photosynthetic protein in plants to know how near-infrared light is converted into electrical charge. This study explores the insight of the efficiency & limits to the photosynthesis process i.e life-giving process. The chlorophyll used by the plants & algae to absorb energy from sun initiates photosynthesis at wavelength up to 720nm. This is the red part of the light spectrum ranging in the visibility region for the human eye. Bacteria, however, can extend this limit of wavelength into near infra-red region. The research was acted on photosynthetic LH1-RC complex obtained from bacterium Blastochloris Viridis, which has the ability to harvest and use light at wavelengths more than 1,000 nm. Cryo-electron microscopy is used to determine the structure of this complex which depicts how near-infrared light is converted to electrical charge which boosts cell metabolism in the bacterium allowing it to live at an extreme re...

How to Tell If You’re Carbohydrate Intolerant—And Yeah, It's a Thing

  Carbohydrate , Carbohydrate, Carbohydrate. The ‘other’ c-word that truly divides rooms. Should we eat them? Are they terrible for our health? Are brown ones better than white ones? Why are they so demonized? Carbohydrates are an integral part of any diet, but the amount that works within someone’s diet is a grey area—meaning what works for one person may not work for another. If we are used to feeling a bit on the side of life after consuming carbohydrate, it should be known that carbohydrate intolerance is totally a thing and should be taken into consideration when assessing which type of diet is best for us. What is carbohydrate intolerance? Carbohydrate intolerance is the failure to digest one or many carbohydrates due to a lack of one or more gastrointestinal enzymes. The symptoms may include diarrhea, bloating, nausea and flatulence, an official diagnosis can be made by a hydrogen or methane breath test.               ...