T helper 17 (T-h17) cells have essential functions in autoimmune diseases and inflammation belonging to a group of T cells. To maintain self-tolerance and prevent autoimmune responses, Regulatory T cells (iTregs) are used to function suppressively.
Proteins are one of the important biomolecules forming the functional and structural entity of a living cell. To determine the set of proteins expressed by a cell, tissue, or organism at a certain time mass spectrometry-based quantitative proteomics can be used.
The immune system protects the body against harmful pathogens and tumors providing self-tolerance. T-helper cells play critical roles in controlling immune reactions as they are the major components of the adaptive system.
The label-free quantitative proteomics which is an advanced technology is utilized to identify the proteomes of Th17 and iTreg cells. This technology has generated a resource that is used to identify over 4000 proteins expressed in Th17 and iTreg cells.
The analysis of both proteome and gene expression data was combined to discover the changes in protein expression that was not associated with changes at the transcriptional level. The identified proteins are targeted potentially in immunotherapy for disease conditions like cancer and autoimmunity.
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