structural-biology meet

A new mathematical approach incorporates personalized details to simulate the metabolic effects of exercise which can be adapted to different individual characteristics, such as age and weight, as well as different types and intensities of exercise.  Physical activity helps to prevent or treat metabolic diseases and to understand better of the molecular effects of exercise that could aid clinical efforts to address the disease. It is difficult to monitor in people the system-level effects of exercise, so the scientists have developed mathematical models to simulate them. However, previously developed models don’t provide key details such as exercise type and personal characteristics. To address this challenge, the existing model was extended to make it more personalized which used known properties of different organs and tissues to simulate the effects of exercise on metabolic dynamics of glucose, hormones, and related substances in those tissues. However, the model...

To reduce drug development cost a new way is developed which is more accurate & efficient for modeling molecules & chemical reactions in liquid solutions allowing the chemists to understand molecule synthesis process details. This software is developed for the need to better understand molecular reaction in liquids. A molecule is expected to behave in a certain manner & the recent models allow us to predict its behavior in the vacuum only where the molecules are isolated.  We also know that drugs are supposed to interact with the liquid they surround like blood. Till now there is no way to predict the behavior of molecules in liquids where the drug will actually make the effect. After knowing this, the question how the molecules change on being put into the liquid surrounding them is answered. In the quantum chemistry, modeling liquids is still a big challenge. It is still not known how to model water model &molecules model when they are dissolved. Molecule...

Scientist finds the solution for the structure of a photosynthetic protein in plants to know how near-infrared light is converted into electrical charge. This study explores the insight of the efficiency & limits to the photosynthesis process i.e life-giving process. The chlorophyll used by the plants & algae to absorb energy from sun initiates photosynthesis at wavelength up to 720nm. This is the red part of the light spectrum ranging in the visibility region for the human eye. Bacteria, however, can extend this limit of wavelength into near infra-red region. The research was acted on photosynthetic LH1-RC complex obtained from bacterium Blastochloris Viridis, which has the ability to harvest and use light at wavelengths more than 1,000 nm. Cryo-electron microscopy is used to determine the structure of this complex which depicts how near-infrared light is converted to electrical charge which boosts cell metabolism in the bacterium allowing it to live at an extreme re...